Can I Participate?

You may be eligible to participate in the GLADIATOR UC clinical trial if you:

Are 18-80 years of age

Were diagnosed with ulcerative colitis (UC) at least 3 months ago

Have previously been on a UC treatment which did not work or which you could not tolerate

Are currently experiencing
an active flare*

Other eligibility criteria apply.
* A flare usually consists of symptoms like frequent or urgent bowel movements, diarrhea, bloody stool, and/or abdominal pain.
You may also experience fatigue, a lack of appetite, and weight loss.

In the GLADIATOR UC study, you will be seen by UC specialists, help advance UC research, and you may receive an investigational drug that is being evaluated to see if it may reduce your UC symptoms. Patients must be in flare (experiencing active symptoms) to participate in the GLADIATOR UC study.

What You May Receive

  • Travel, lodging and meal reimbursements for clinic visits
  • Medical treatment related to Ulcerative Colitis
  • Study related treatment at no cost

What's Involved

Step 1

Application

Click here to see if you may qualify

Step 2

Phone Call

Upon initial eligibility, a patient outreach representative will call you and help guide you through additional eligibility questions

Step 3

Official Screening

The team at a participating study center will determine if you are eligible to participate in the study and what would be required for participation

Step 4

Study

Throughout the study, you will take the investigative treatment daily and have a mix of virtual and in person visits, depending on your needs. You will be asked to keep a diary to record specific experiences and answer questions about your experience living with UC

Why Should I Participate?

We are looking for participants with active symptoms (in flare) to take part in important research, intended to improve UC symptoms and treatment options.
"Maple was the only provider that could support our growth ambitions."
Gianna Johnson
Director@Company
"Maple was the only provider that could support our growth ambitions."
Gianna Johnson
Director@Company

By enrolling in this Phase 2 trial, you may be given an investigational drug being evaluated for:

  • Potential treatment of moderate ulcerative colitis
  • Relieving the signs and symptoms of moderate UC such as:
  • Pain and inflammation
  • Number of stools per day without blood
  • Abdominal cramps and pain
Participate in the GLADIATOR study

You will be seen by UC specialists and your participation in this study will help lead to a better understanding of the investigational drug.

FAQs

How do I get started?

Click here and enter your information to express interest in the study.

What does “flare” or “active symptoms” mean?

A “flare” or “active symptoms” usually consist of issues like frequent or urgent bowel movements, diarrhea, bloody stools, and/or abdominal pain. You may also experience fatigue, lack of appetite and weight loss.

What if I am not currently experiencing symptoms (not in flare)?

You can still fill out the questionnaire at this time. We’ll save your information and send you reminders to check if you may pre-qualify at a later date. Alternatively, you can return to this website when you are experiencing symptoms (a flare) to see if you then pre-qualify.

How will the investigational drug be taken?

The drug will be taken orally (by mouth) once per day.

Can I leave the study at any time?

You’re free to withdraw from the study at any time. If you sign up, your participation is completely voluntary.

Does participating in this trial cost me anything?

There is no cost to either you or your insurance provider for participation in this trial. You may be reimbursed for your travel expenses.

Do I need health insurance to participate?

No, health insurance is not required to participate in the Arena IBD studies.

Has this investigational drug been tested before?

Etrasimod has been tested in small numbers of healthy volunteers and in people with medical conditions, including UC.

Why did I “not qualify”?

Research studies are rigorously designed to test the investigational drug for safety and effectiveness. One or more of your answers have placed you outside of the strict guidelines for this trial. That does not mean, however, that you will not qualify for different research studies either now or in the future.

What is the importance of clinical studies for UC?

The aim of current treatments is to reduce the signs and symptoms of UC. The available treatments may improve symptoms for some people, but they may have unacceptable side effects, be difficult to stick to, or not work well for others. Therefore, there is a need to develop and find new treatments for people with UC through clinical studies.

About The Sponsor

Arena Pharmaceuticals was founded in 1997 and now operates from three locations – San Diego, California and Boston, Massachusetts in the US and Zug, Switzerland.

It is their mission to improve the lives of those suffering from IBD around the world. They know that living with IBD isn’t always easy and this drives their commitment to discover new treatments and help them to become available to patients.